[PDF][PDF] Evaluation of Analgesic Effect of Human Saliva

S Sarfaraz, S Ramzan, T Bano, W Fatima, A Sabir - J Anal Pharm …, 2017 - academia.edu
… Thus opiorphin acts by activating endogenous opioid dependent transmission and said
to be the modulator of opioid pathways in humans. In accordance with …

[PDF][PDF] An analgesic to bridge the gap between Narcotics and NSAIDs: opiorphin

S Sujatha, R Priyadharshini… - Int J Basic Clin …, 2018 - researchgate.net
Human opiorphin is described as “a natural antinociceptive modulator of opioid-dependent
pathways”. … Human Opiorphin, a natural antinociceptive modulator of …

Human opiorphin an endogenous inhibitor of enkephalin-inactivating ectopeptidases that displays antinociception: A review

M Wollemann, C Rougeot - Current Bioactive Compounds, 2016 - ingentaconnect.com
… , that human opiorphin is “a natural antinociceptive modulator of opioid-dependent pathways”.
… The antidepressant-like effect of human opiorphin via opioid dependent pathways in mice. …

STR-324, a stable analog of opiorphin, causes analgesia in postoperative pain by activating endogenous opioid receptor–dependent pathways

P Sitbon, A Van Elstraete, L Hamdi, V Juarez-Perez… - …, 2016 - pubs.asahq.org
Opiorphin is a naturally occurring potent analgesic human peptide. It protects enkephalins
… effects mediated via opioid-dependent antinociceptive pathways. Opiorphin analog should …

Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system

P Luo, X Li, Y Gao, Z Chen, Q Zhang… - Frontiers in …, 2022 - frontiersin.org
… Here, we investigated the effect of natural enkephalinase inhibitor human opiorphin (HO) on
… colitis by inhibiting TLR4/NF-κB pathway activation and improving intestinal barrier function …

Assessment of salivary opiorphin in oral lichen planus

Z Dalirsani, M Amirchaghmaghi, A Ghazi… - Brazilian Journal of …, 2023 - SciELO Brasil
Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc
Natl Acad Sci US A. 2006 Nov;103(… Human Opiorphin, a natural antinociceptive modulator of …

Influence of STR-324, a Dual Enkephalinase Inhibitor, on Postoperative Pain Scores: A Proof-of-Concept Trial in Patients after Laparoscopic Surgery

T van Dasselaar, I van der Wal, M van Velzen… - …, 2024 - pubs.asahq.org
… Both opiorphin and STR-324 are naturally present in humans, because opiorphin rapidly …
of STR-324 is only possible when endogenous pain modulation is active (and enkephalins are …

[PDF][PDF] Quantitative analysis and expression of salivary opiorphin in painful oral soft-tissue conditions: A descriptive study

NK Nejad, KA RP, S Sujatha - J Global Oral Health, 2020 - researchgate.net
Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc
… The antidepressant-like effect of human opiorphin via opioiddependent pathways in mice. …

The opiorphin analog STR-324 decreases sensory hypersensitivity in a rat model of neuropathic pain

A Van Elstraete, P Sitbon, L Hamdi… - Anesthesia & …, 2018 - journals.lww.com
pathways, which are activated by endogenous opioid peptides, play a major role in the
modulation … have previously demonstrated that the antinociceptive effect of opiorphin 13 , 16 and …

Tear opiorphin levels in ocular pain caused by corneal foreign body

S Ozdogan, C Sonmez, D Yolcu, M Gungormus - Cornea, 2020 - journals.lww.com
… stimulation and exert a potent antinociceptive effect. However, the … endogenous opioid-dependent
transmission, opiorphinOpiorphin is a naturally occurring human peptide that protects …